International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc
Journal website https://ijcp.elmerpub.com

Original Article

Volume 15, Number 1, March 2026, pages 1-7

Complications of Autosomal Dominant Polycystic Kidney Disease in Pediatrics: A Twenty-Five-Year Experience

Figures

↓  Figure 1. Relationship between kidney length Z-score and the presence of ADPKD-related complications in children with ADPKD. Box-and-whisker plot showing the distribution of kidney length Z-scores in patients with and without complications. ADPKD: autosomal dominant polycystic kidney disease.
Figure 1.
↓  Figure 2. Relationship between kidney length Z-score and estimated glomerular filtration rate (eGFR) in children with ADPKD. Scatter plot illustrating eGFR values across kidney length Z-scores in the study cohort. ADPKD: autosomal dominant polycystic kidney disease.
Figure 2.
↓  Figure 3. Relationship between age and estimated glomerular filtration rate (eGFR) in children with ADPKD. Scatter plot with linear regression showing the association between age and eGFR. ADPKD: autosomal dominant polycystic kidney disease.
Figure 3.
↓  Figure 4. Relationship between largest cyst dimension and the presence of ADPKD-related complications in children with ADPKD. Box-and-whisker plot showing the distribution of largest cyst dimensions in patients with and without complications. ADPKD: autosomal dominant polycystic kidney disease.
Figure 4.
↓  Figure 5. Relationship between cyst complexity and estimated glomerular filtration rate (eGFR) in children with ADPKD. Box-and-whisker plot showing eGFR values according to Bosniak cyst complexity categories (II and IIF). ADPKD: autosomal dominant polycystic kidney disease.
Figure 5.

Table

↓  Table 1. Demographic, Clinical, and Imaging Characteristics of Pediatric Patients With ADPKD
 
VariableWith complications (n = 19)Without complications (n = 48)P-value
Continuous variables are presented as mean ± SD and categorical variables as number (%). P-values represent comparisons between patients with and without ADPKD-related complications. ADPKD: autosomal dominant polycystic kidney disease; eGFR: estimated glomerular filtration rate.
Female sex, n (%)13 (68.4%)22 (45.8%)0.008
Age at evaluation (years), mean ± SD14.2 ± 5.210.9 ± 5.00.015
Weight percentile52.158.40.413
Kidney length Z-score, mean ± SD2.4 ± 2.72.2 ± 2.20.941
Largest cyst diameter (cm), mean ± SD2.3 ± 1.52.5 ± 1.90.896
Number of renal cysts ≥ 10, n (%)12/19 (63.2%)28/48 (58.3%)0.863
Bosniak classification, n (%)0.785
  Bosniak I11/19 (57.9%)28/48 (58.3%)
  Bosniak II7/19 (36.8%)19/48 (39.6%)
  Bosniak IIF1/19 (5.3%)1/48 (2.1%)