↓ Figure 1. Study selection for systematic review.
| International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc |
| Journal website https://ijcp.elmerpub.com |
Original Article
Volume 15, Number 1, March 2026, pages 8-15
Efficacy of Teduglutide for Pediatric and Short Bowel Syndrome-Associated Intestinal Failure: A Systematic Review
Figures
Tables
| Study | Study design | Patients (TED/SOC) | Female sex (TED/SOC) | Age (years) (TED/SOC) | Weight z-score, mean at baseline (TED/SOC) | Height z-score, mean at baseline (TED/SOC) | Baseline BMI (TED/SOC) | Patients with remaining colon (TED/SOC) |
|---|---|---|---|---|---|---|---|---|
| Data are presented as mean values unless otherwise specified. BMI: body mass index; NR: not reported; SOC: standard of care; TED: teduglutide. | ||||||||
| Fifi et al, 2023 [8] | Post-hoc exploratory analysis | 87/14 | 27/5 | 5.7/4.4 | −0.3/0.2 | −0.3/0.5 | −0.1/−0.1 | 82/11 |
| Chiba et al, 2023 [9] | Secondary analysis | 7/5 | 2/2 | 8.9/8.3 | −1.5/−0.6 | −1.5/0.1 | NR | 7/5 |
| Kocoshis et al, 2020 [7] | Phase III clinical trial | 50/9 | 8/7 | 6.5/6 | −0.9/−0.2 | −1.3/−0.4 | −0.1/0.1 | NR |
| Study | Bias from randomization process | Bias due to deviations from intended interventions | Bias due to missing outcome data | Bias in measurements of outcomes | Bias in selection of the reported result | Overall risk of bias |
|---|---|---|---|---|---|---|
| Risk of bias was assessed using Cochrane RoB 2 tool. | ||||||
| Fifi et al, 2023 [9] | Low | Low | Low | Some concerns | Low | Some concerns |
| Chiba et al, 2023 [8] | Some concerns | Low | Low | Some concerns | Low | Some concerns |
| Kocoshis et al, 2020 [7] | Low | Low | Low | Low | Low | Low |