International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc
Journal website https://ijcp.elmerpub.com

Case Report

Volume 14, Number 2, October 2025, pages 51-54

A Case of Homozygous Beta+-Thalassemia

Figures

↓  Figure 1. Clinical image. Note the marked pallor, prominent forehead, flat nasal bridge, marked prominence of the maxilla, gingival hypertrophy with disordered dentition and grossly distended abdomen.
Figure 1.
↓  Figure 2. Thin blood film. Thin blood film fixed in methanol and stained with Leishman stain; × 1,000 magnification. Note the markedly abnormal red cell morphology, including anisocytosis, hypochromasia, poikilocytosis, numerous nucleated red cells, fragmented cells, target cells and tear drop cells and no evidence of a marked leukocytosis.
Figure 2.

Table

↓  Table 1. Hematological Findings
 
Patient Father
Normal reference ranges are shown in parentheses. Hb: hemoglobin; HbF: fetal hemoglobin; HbA: adult hemoglobin.
Hb concentration (g/dL) 6.1 (11.5 - 14.0) 13.8 (14.0 - 18.0)
Mean cell volume (fL) 61 (80 - 100) 64.1 (80 - 100)
Mean cell Hb (pg) 16.1 (27.0 - 31.0) 22.2 (27.0 - 31.0)
Red blood cell count (1012/L) 2.3 (4.0 - 5.5) 6.2 (4.0 - 5.5)
Reticulocytes (%) 10.7 (0.4 - 3.0) -
Hb electrophoresis Predominantly HbF, with some HbA and a raised HbA2 Predominantly HbA with a raised HbA2
HbA2 (%) 4.5 (2.5 - 3.1) 4.1 (2.5 - 3.1)
White blood cell count (109/L) 75.8 (4.5 - 11.0) -
White blood cell differential (%) Lymphocytes 68.3% (20 - 40); granulocytes 25.5 (41.5 - 68.0) -