International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc
Journal website https://ijcp.elmerpub.com

Case Report

Volume 000, Number 000, October 2025, pages 000-000

A Case of Homozygous Beta+-Thalassemia

Figures

Figure 1.
Figure 1. Clinical image. Note the marked pallor, prominent forehead, flat nasal bridge, marked prominence of the maxilla, gingival hypertrophy with disordered dentition and grossly distended abdomen.
Figure 2.
Figure 2. Thin blood film. Thin blood film fixed in methanol and stained with Leishman stain; × 1,000 magnification. Note the markedly abnormal red cell morphology, including anisocytosis, hypochromasia, poikilocytosis, numerous nucleated red cells, fragmented cells, target cells and tear drop cells and no evidence of a marked leukocytosis.

Table

Table 1. Hematological Findings
 
PatientFather
Normal reference ranges are shown in parentheses. Hb: hemoglobin; HbF: fetal hemoglobin; HbA: adult hemoglobin.
Hb concentration (g/dL)6.1 (11.5 - 14.0)13.8 (14.0 - 18.0)
Mean cell volume (fL)61 (80 - 100)64.1 (80 - 100)
Mean cell Hb (pg)16.1 (27.0 - 31.0)22.2 (27.0 - 31.0)
Red blood cell count (1012/L)2.3 (4.0 - 5.5)6.2 (4.0 - 5.5)
Reticulocytes (%)10.7 (0.4 - 3.0)-
Hb electrophoresisPredominantly HbF, with some HbA and a raised HbA2Predominantly HbA with a raised HbA2
HbA2 (%)4.5 (2.5 - 3.1)4.1 (2.5 - 3.1)
White blood cell count (109/L)75.8 (4.5 - 11.0)-
White blood cell differential (%)Lymphocytes 68.3% (20 - 40); granulocytes 25.5 (41.5 - 68.0)-